产品分类
RN-486
- CAS NO.：1242156-23-5
- 品牌名称：LKT Labs
- 品牌货号：R5212-1 mg
- 产品级别：≥98%
- 包装规格：1 mg
- 本店售价：3,803.924,475.20
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产品介绍
RN-486,,货号:R5212-1 mg,品牌:LKT Labs
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RN-486 is an inhibitor of Bruton’s tyrosine kinase (Btk) that is currently in development as a potential treatment for rheumatoid arthritis; it exhibits anti-inflammatory, nephroprotective, and immunosuppressive activities. RN-486 decreases production of IL-6 and expression of IL-8, TNF, MMP1, and MMP10 in synovial tissue. In animal models of systemic lupus erythmatosus (SLE), RN-486 inhibits B-cell activation and anti-double-stranded DNA IgG production, suppressing progression of glomerulonephritis. In other animal models, this compound inhibits mast cell degranulation, preventing type I and III hypersensitivity responses and limiting joint and systemic inflammation. RN-486 also decreases TLR-9 signaling and cytokine production.