产品分类
PD-98059
- 中文名称：2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮
- CAS NO.：[167869-21-8]
- 品牌名称：Wako
- 品牌货号：169-19211
- 产品级别：95+% (TLC),生物化学
- 包装规格：5mg
- 本店售价：2,260.002,490.00
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产品介绍
PD-98059,2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮,货号:169-19211,品牌:Wako
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Mitogen Activated Protein Kinaze(MAPK)-1 inhibitor.The product has been reported to inhibit MAP kinase activation by insulinand block completely the increase in cell growthand MAP activity induced by leptin (obesity regulating hormone).The resting cell pretreated with PD-98059 has been demonstrated to inhibit a great deal the expression of the advance early genes c-fos and eggr-1 induced by a peroxisome proliferative agent.
MAP (Mitogen Activated Protein) kinase (MAPK) is a kind of serine/threonine kinase that is activated by stimuli including extracellular stress, especially cell proliferation and differentiation. It is present in any eukaryote and plays a key role in various signal transduction pathways. Three types of kinases, according to phosphorylation, i.e. MAPK, MAP kinase kinase (MAPKK), and MAP kinase kinase kinase (MAPKKK) are known. In recent years, related cascades have been found, including p38MAPK, JNK, MEK1/2 and ERK3/5 cascades, which are the focus of detailed research.
Research for ES/iPS cell
Reagents for ES cell culture and iPS cell induction
Maintain ES & iPs cells in an undifferentiated state
Improve reprogramming efficiency
MAPK Inhibitor
Promotes self propagation of embryonic stem cells.