产品分类
INI-0602, 98.0+ % (HPLC)
- CAS NO.：[1204185-14-7]
- 品牌名称：Wako
- 品牌货号：097-06511
- 产品级别：98.0+ % (HPLC), 细胞生物学
- 包装规格：1 mg
- 本店售价：2,090.002,300.00
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产品介绍
INI-0602, 98.0+ % (HPLC),INI-0602, 98.0+ % (HPLC),货号:097-06511,品牌:Wako
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In recent reports, Glutamate released by activated microglia induces excitotoxic neuronal death, which likely contributes to non-cell autonomous neuronal death in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS)jand Alzheimer's disease.
INI-0602 is a novel blood-brain barrier permeable gap junction hemichannel blocker, that effectively inhibits neurotoxic microglial glutamate release.
Features:
Blood-brain barrier permeable.
Inhibits neurotoxic microglial glutamate release and excitotoxic neuronal death of cultured mouse primary neurons in microglia-conditioned media (in vitro).
Ameliorates disease symptoms in ALS and AD mouse models (in vivo).