免疫检查点活性蛋白及相关产品 CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3
发布时间：2023-11-16 点击数：108
免疫检查点活性蛋白及相关产品CTLA-4,PD-1,IDO1,B7-H4,LAG-3,Tim-3
◆活性免疫检测点蛋白
B7-H4 (human):Fc (human) (rec.) | CHI-HF-210B7H4 |
B7-H4 (mouse):Fc (mouse) (rec.) | CHI-MF-110B7H4 |
CTLA-4 (human):Fc (human) (rec.) | CHI-HF-210A4 |
CTLA-4 (human):Fc (human) (rec.) (non-lytic) | CHI-HF-220A4 |
CTLA-4 (human):Fc (mouse) (rec.) | CHI-HF-211A4 |
CTLA-4 (mouse):Fc (mouse) (rec.) | CHI-MF-110A4 |
CTLA-4 (mouse):Fc (mouse) (rec.) (non-lytic) | CHI-MF-120A4 |
PD-1 (human):Fc (human) (rec.) | CHI-HF-210PD1 |
PD-1 (human):Fc (human) (rec.) (non-lytic) | CHI-HF-220PD1 |
PD-1 (mouse):Fc (mouse) (rec.) | CHI-MF-110PD1 |
PD-L1/B7-H1 (human):Fc (human) (rec.) | CHI-HF-210PDL1 |
PD-L1/B7-H1 (human):Fc (human) (rec.) (non-lytic) | CHI-HF-220PDL1 |
PD-L1/B7-H1 (mouse):Fc (mouse) (rec.) | CHI-MF-110PDL1 |
PD-L1/B7-H1 (mouse):Fc (mouse) (rec.) (non-lytic) | CHI-MF-120PDL1 |
PD-L2 (human):Fc (human) (rec.) | CHI-HF-210PDL2 |
PD-L2 (human):Fc (human) (rec.) (non-lytic) | CHI-HF-220PDL2 |
PD-L2 (mouse):Fc (mouse) (rec.) | CHI-MF-110PDL2 |
◆IDO1酶&主要抑制剂
IDO1 (human) Enzyme+Inhibitor Set | AG-44B-0006 |
IDO1 (human) (rec.) (His) (highly active) | AG-40B-0161 |
MMG-0358 Potent Triazole IDO1 Inhibitor AG-CR1-3630
IC50值，mIDO1细胞检测是2 nM，hIDO1细胞检测是80 nM，hIDO1（pH 6.5）酶活检测是330 nM，hIDO1（pH7.4）的酶活检测是71 nM。体内有活性。
参考文献
Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition: U.F. Roehrig, et al.; J. Med. Chem. , 55, 5270 (2012)
◆肿瘤免疫治疗的LAG-3
功能性封闭抗体 | |
LAG-3 (human), mAb (blocking) (17B4) | AG-20B-0012 |
LAG-3 (human), mAb (blocking) (17B4) (preservative free) | AG-20B-0012PF |
LAG-3, mAb (blocking) (11E3) | AG-20B-0011 |
LAG-3, mAb (blocking) (11E3) (preservative free) | AG-20B-0011PF |
生物活性蛋白 | |
LAG-3 (human):Fc (human) (rec.) | AG-40B-0031 |
LAG-3 (mouse):Fc (mouse) (rec.) | AG-40B-0039 |
◆T-细胞免疫球蛋白和粘蛋白结构域
Tim-3 (human):Fc (human) (rec.) | CHI-HF-210T3 |
Tim-3 (mouse):Fc (mouse) (rec.) | CHI-MF-110T3 |
◆CD1d配体抗肿瘤佐剂
α-Galactosylceramide | Potent NKT Cell stimulator 强有效NKT 激活剂 | AG-CN2-0013 |
在人类和小鼠NKT细胞里MHC-I蛋白和CD1d分子脂质结合的特异性配体。
参考文献
LIT: Combination of the toll like receptor agonist and α-Galactosylceramide as an efficient adjuvant for cancer vaccine: F. Gableh, et al.; J. Biomed. Sci., 23, 16 (2016)
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